Gestational acrylamide exposure and biomarkers of fetal growth: Probing the mechanism underlying the association between acrylamide and reduced fetal growth

Four epidemiological studies have shown a negative association between prenatal acrylamide exposure and birth size. In order to shed light on the possible underlying mechanism(s), we analysed associations biomarkers related fetal growth. newborns of ENVIRONAGE cohort (n ranges from 215 434), investigated (acrylamide glycidamide hemoglobin adduct levels in cord blood) thyroid hormones (TSH, T3, T4 ratio T3 plasma), insulin-related factors (cord plasma insulin IGF1, placental IGF2), neurotrophins BDNF, NGF, NT3 NT4), homocysteine progesterone, using multiple linear regression analysis. addition, whether mediated outcomes. We observed lower TSH (?10.2% [95% CI: ?15.0, ?4.3]) higher NGF (10.0% CI 3.7, 17.4]) for twofold increase adducts, decrease free with adducts ?2.9% (95% ?5.7, ?0.1) ?3.9% ?6.2, ?1.6) levels, respectively, increases both 2.8% 0.2, 5.6) 3.6% 0.8, 6.6) respectively. Additionally, was associated particularly among non-smoking mothers (?11.2% ?19.5, ?0.1]). Cord seemed mediate weight. A may be (a marker of) mechanism by which gestational is decreased The health consequences warrant future study.